Usefulness of the detection of Toxoplasma gondii antigens in AIDS patients

Author:

Fachado Alberto,Fonte Luis,Alberti Esteban,Hadad Pablo,Fonseca Lisset,Machin Rodolfo,Finlay Carlos

Abstract

Toxoplasmic encephalitis (TE) is a mayor cause of central nervous system infection in patients with acquired immunodeficiency syndrome (AIDS). Toxoplasma antibodies were detected in 56 of 79 patients with AIDS (71%), in the present study. Fourteen out of 57 seropositive patients developed TF (25%) and had Toxoplasma gondii antigen detected in their urine. For this, most of them received an effective therapy, with the subsequent disappearance of the symptoms and discontinuity of excretion of the T. gondii antigens. Our results suggest that the monitoring of T. gondii antigen in the urine of AIDS patients may be useful to decide on the proper time for therapy, as well as to avoid the beginning of neurologic signs in these patients.

Publisher

FapUNIFESP (SciELO)

Subject

Infectious Diseases,General Medicine

Reference19 articles.

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3. Serological observations on toxoplasmosis in Zairian AIDS patients;DE CLERCQ D.;Trans. roy. Soc. trop. Med. Hyg.,1986

4. Serological study of the prevalence of toxoplasmosis in 167 patients with acquired immunodeficiency syndrome (AIDS) or chronic lymphadenopathy syndrome (LAS);DEROUIN F.;Biomed. Pharmacother.,1986

5. Technique for the detection of Toxoplasma gondii antigens in mouse urine;FACHADO A.;Mem. Inst. Oswaldo Cruz,1990

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