Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids-Reference-Cited by-同舟云学术

Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids

Published:2012 Issue:6 Volume:33 Page:309-312
ISSN:0278-0240
Container-title:Disease Markers
language:en
Short-container-title:Disease Markers

Author:

Demarco Ana Lúcia G.¹,Rodrigues Maria de Lourdes V.¹,Figueiredo José Fernando C.²,Deghaide Neifi Hassam S.²,de Menezes Marcelo Bezerra²,Demarco Luís A.¹,Fernandes Ana Paula M.³,Donadi Eduardo A.²

Affiliation:

1. Department of Ophthalmology, Otorhinolaringology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

2. Department Medical Clinical, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

3. Department of General and Specialized Nursing, Nursing School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

Abstract

Background/aims: The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC).Methods: 98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies and without TCR) were studied.Results: The HLA-B35 was significantly increased in TRC group (p= 0.0038).Conclusion: The presence of HLA-B35 may simultaneously predispose to progression to AIDS and TRC.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/dm/2012/612030.pdf

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