Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives-Reference-Cited by-同舟云学术

Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives

Published:2013-12 Issue:4 Volume:49 Page:903-909
ISSN:1984-8250
Container-title:Brazilian Journal of Pharmaceutical Sciences
language:
Short-container-title:Braz. J. Pharm. Sci.

Author:

Singh Anita¹,Lakshmayya ²,Asif Mohammad²

Affiliation:

1. Institute of Management and Technology, India

2. Kumaun University, India

Abstract

Several 6-aryl-4-substituted benzylidene/furfurylidene pyridazin(2H)-3-one derivatives (4a-f) were synthesized and evaluated as analgesic and anti-inflammatory agents in mice and rats, respectively. All compounds were tested by using Eddy's hot plate and the carrageenan-induced hind paw oedema method for the evaluation of analgesic and anti-inflammatory activities, respectively. Results showed that compounds 4f, 4b, 4d, and 4e exhibited higher analgesic and anti-inflammatory activities than other remaining compounds. All title compounds (4a-f) were characterized by IR, NMR and Mass spectroscopy.

Publisher

FapUNIFESP (SciELO)

Subject

General Pharmacology, Toxicology and Pharmaceutics

Link

http://www.scielo.br/pdf/bjps/v49n4/v49n4a30.pdf

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