Affiliation:
1. Department for Pesticides Synthesis and Expertise, National Agrarian University of Armenia , Teryan Str. 74 , Yerevan , 0009 , Armenia
Abstract
Abstract
Eco-friendly ultrasound-assisted synthesis of a series of 3-N-substituted 6-((4-(butylamino)-6-(diethylamino)-1,3,5-triazin-2-yl)oxy)pyridazin-3(2H)-one derivatives and in silico study to predict their biological activities were carried out. Physicochemical and pharmacokinetic properties were obtained. Absorption, distribution, metabolism, excretion and toxicity properties and bioavailability index were calculated. A comparative analysis of structural similarity based on the Tanimoto coefficient was carried out.
Subject
Health, Toxicology and Mutagenesis,Industrial and Manufacturing Engineering,Fuel Technology,Renewable Energy, Sustainability and the Environment,General Chemical Engineering,Environmental Chemistry
Reference54 articles.
1. Patel D, Patel R, Kumari P, Patel N. Microwave assisted synthesis and in vitro antimicrobial assessment of quinolone based s-triazines. Heterocycl Commun. 2011;17(1–2):33–41. 10.1515/HC.2011.006.
2. Cholera AY, Ladva KD. A convenient synthesis of trisubstituted 1,3,5-triazine derivatives and their antimicrobial screening. Der Pharm Chem. 2018;10(4):57–61. www.derpharmachemica.com.
3. Al-Rasheed HH, Al Alshaikh M, Khaled JM, Alharbi NS, El-Faham A. Ultrasonic irradiation: synthesis, characterization, and preliminary antimicrobial activity of novel series of 4,6-disubstituted-1,3,5-triazine containing hydrazine derivatives. J Chem. 2016;9:Article ID 3464758. 10.1155/2016/3464758.
4. Vembu S, Pazhamalai S, Gopalakrishnan M. Potential antibacterial activity of triazinedendrimer: Synthesis and controllable drug release properties. Biorg Med Chem. 2015;23(15):4561–6. 10.1016/j.bmc.2015.06.009.
5. Sunduru N, Gupta L, Chaturvedi V, Dwivedi R, Sinha S, Chauhan PMS. Discovery of new 1,3,5-triazine scaffolds with potent activity against mycobacterium tuberculosis H37Rv. Eur J Med Chem. 2010;45:3335–45. 10.1016/j.ejmech.2010.04.017.