Abstract
Primary Sjögren's syndrome (pSS) is the most frequent connective tissue disease, but remains very under diagnosed. Psychiatric manifestations are classified among the central neurological disorders of pSS, and their prevalence is variously estimated according to the series and the recruitment services: 20-70% of cases. They may be the predominant manifestations of the disease, but pSS remains an underestimated cause of neuropsychiatric disorders. The inaugural psychiatric presentations of this disease are exceptional and represent a real diagnostic challenge for clinicians. We report an original observation of depression as an initial and isolated manifestation revealing neuro-Sjögrenina 60-year-old woman. Only a few similar sporadic cases were previously reported in the world literature. As rare as it is, this clinical presentation of pSS deserves to be known by any healthcare professional.