PGAM1 and TP53 mRNA levels in canine mammary carcinomas – Short communication-Reference-Cited by-同舟云学术

PGAM1 and TP53 mRNA levels in canine mammary carcinomas – Short communication

Published:2021-06-05 Issue:1 Volume:69 Page:50-54
ISSN:0236-6290
Container-title:Acta Veterinaria Hungarica
language:
Short-container-title:AVet

Author:

Maués Tábata¹^ORCID,Oliveira Táya Figueiredo de¹,El-Jaick Kênia Balbi²,Figueiredo Agnes Marie Sá³,Ferreira Maria De Lourdes Gonçalves¹,Ferreira Ana Maria Reis¹

Affiliation:

1. 1Department of Pathology and Veterinary Clinic, Faculty of Veterinary, Universidade Federal Fluminense, Av. Alm. Ary Parreiras, 507, Icaraí, 24220-000, Niterói, RJ, Brazil

2. 2Department of Genetics and Molecular Biology, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

3. 3Department of Medical Microbiology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Abstract

AbstractTP53 and PGAM1 genes play a key role in glycolysis which is an essential metabolic pathway of cancer cells for obtaining energy. The purpose of this work was to evaluate PGAM1 and TP53 mRNA expressions in canine mammary carcinomas (CMC) and to correlate them with animal data and tumour histological features. None of the nine samples analysed revealed PGAM1 DNA sequence variations. PGAM1 and TP53 RNA expressions from 21 CMC were analysed using a one-step reverse transcription-PCR kit and its platform system. Most CMC samples had low levels of PGAM1 mRNA (71.5%) and normal expression of TP53 mRNA (95.2%). Our results suggest a different feature of the Warburg effect on canine mammary cancer cells compared to human cells.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Akademiai Kiado Zrt.

Subject

General Veterinary

Link

https://akjournals.com/downloadpdf/journals/004/69/1/article-p50.xml

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