Fabrication Of Glimepiride Datura Stramonium Leaves Mucilage And Poly Vinyl Pyrrolidone Sustained Release Matrix Tablets: In Vitro Evaluation

Author:

Hindustan Abdul Ahad,Babu U Anand,Nagesh K,Kiran D Sai,Madhavi K Bindu

Abstract

The main purpose of the present work was to develop matrix tablets of Glimepiride with Datura stramonium leaves mucilage and Poly Vinyl Pyrrolidone and to study its functionality as a matrix forming agent for sustained release tablet formulations. Mucilage from Datura stramonium leaves was extracted, isolated, purified and characterized. Physicochemical properties of the dried powdered mucilage of Datura stramonium leaves were studied. Various formulations of Glimepiride Datura stramonium leave mucilage and Poly Vinyl Pyrrolidone were prepared. The formulated tablets were tested for mechanical properties, friability, swelling behavior, in vitro drug release pattern and the dissolution data was treated with mathematical modeling and the optimized formulation was tested for accelerated stability studies. The formulated tablets were found to have good mechanical properties, good swelling properties. The in vitro dissolution data was perfectly fitting to zero order and the release of drug from the formulation followed Higuchi’s release. The accelerated stability studies revealed that the tablets retain their characteristics even after stressed storage conditions. From this study it was concluded that the dried Datura stramonium leaves mucilage and Poly Vinyl Pyrrolidone combination can be used as a matrix forming material for making sustained release matrix tablets. DOI: http://dx.doi.org/10.3126/kuset.v8i1.6044 KUSET 2012; 8(1): 63-72

Publisher

Nepal Journals Online (JOL)

Subject

General Medicine

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