Author:
Li Guoyong,Cheng Tao,Yu Xuefeng
Abstract
Osteoarthritis (OA) is a progressive degenerative disease characterized by cartilage degradation, synovial inflammation, subchondral sclerosis and osteophyte formation. It has a multifactorial etiology with potential contributions from heredity, endocrine function, abnormal mechanical load and nutrition. Of particular considerations are trace element status. Several trace elements, such as boron and magnesium are essential for normal development of the bone and joint in human. While cadmium correlates with the severity of OA. The present review focuses on the roles of trace elements (boron, cadmium, copper, iron, magnesium, manganese, selenium, zinc) in OA and explores the mechanisms by which they act.
Reference154 articles.
1. Characterization of synovial fluid metabolomic phenotypes of cartilage morphological changes associated with osteoarthritis;Carlson;Osteoarthritis Cartilage.,2019
2. Effects of biological factors and health condition on mercury and selenium concentrations in the cartilage, meniscus and anterior cruciate ligament;Kosik-Bogacka;J Trace Elem Med Biol.,2017
3. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017;Lancet (London, England).,2018
4. Risk of knee osteoarthritis with obesity, sarcopenic obesity, and sarcopenia;Misra;Arthritis Rheumatol (Hoboken, NJ).,2019
5. Disability, physical impairments, and poor quality of life, rather than radiographic changes, are related to symptoms in individuals with ankle osteoarthritis: a cross-sectional laboratory study;Al-Mahrouqi;J Orthop Sports Phys Ther.,2020
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