Author:
Silva Thaís de Souza,Salvato Richard Steiner,Gregianini Tatiana Schäffer,Gomes Ighor Arantes,Pereira Elisa Cavalcante,de Oliveira Eneida,de Menezes André Luiz,Barcellos Regina Bones,Godinho Fernanda Marques,Riediger Irina,Debur Maria do Carmo,de Oliveira Cristina Mendes,Ribeiro-Rodrigues Rodrigo,Miyajima Fabio,Dias Fernando Stehling,Abbud Adriano,Monte-Neto Rubens do,Calzavara-Silva Carlos Eduardo,Siqueira Marilda Mendonça,Wallau Gabriel Luz,Resende Paola Cristina,Fernandes Gabriel da Rocha,Alves Pedro
Abstract
Recombination events have been described in the Coronaviridae family. Since the beginning of the SARS-CoV-2 pandemic, a variable degree of selection pressure has acted upon the virus, generating new strains with increased fitness in terms of viral transmission and antibody scape. Most of the SC2 variants of concern (VOC) detected so far carry a combination of key amino acid changes and indels. Recombination may also reshuffle existing genetic profiles of distinct strains, potentially giving origin to recombinant strains with altered phenotypes. However, co-infection and recombination events are challenging to detect and require in-depth curation of assembled genomes and sequencing reds. Here, we present the molecular characterization of a new SARS-CoV-2 recombinant between BA.1.1 and BA.2.23 Omicron lineages identified in Brazil. We characterized four mutations that had not been previously described in any of the recombinants already identified worldwide and described the likely breaking points. Moreover, through phylogenetic analysis, we showed that the newly named XAG lineage groups in a highly supported monophyletic clade confirmed its common evolutionary history from parental Omicron lineages and other recombinants already described. These observations were only possible thanks to the joint effort of bioinformatics tools auxiliary in genomic surveillance and the manual curation of experienced personnel, demonstrating the importance of genetic, and bioinformatic knowledge in genomics.
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献