Exploration of Secondary Metabolite Production Potential in Actinobacteria Isolated From Kandelia candel Mangrove Plant

Author:

Hu Dini,Lee Simon Ming-Yuen,Li Kai,Mok Kai Meng

Abstract

Mangroves are extreme inter-tidal environments containing rich microbial communities. Actinobacteria from mangroves have an unprecedented ability to biosynthesize secondary metabolites. Therefore, the secondary metabolite production potential of actinobacteria sourced from mangroves warrants further exploration to determine whether they offer new sources of natural products. For this purpose, we selected a strain of Mycobacterium saopaulense (Actinobacteria phylum) from the mangroves in Macau for whole genome sequencing and tandem mass spectrometry analysis. The results showed that the 5,376,881-bp genome from this strain contains 5,391 protein-coding genes and a coding density of 90.53%. The main participating KEGG pathway was “Metabolism”. Altogether, the 81 gene clusters identified in its genome were associated with the production of 23 secondary metabolites. Sixteen of them were classified as antibiotics and three of them as bioactive compounds. Furthermore, two of the predicted secondary metabolites from the fermentation process were clavulanic acid and streptomycin. Both of these antibiotics were initially found to be produced by the M. saopaulense strain. This study shows that mangrove-derived actinobacteria have a large number of biosynthetic pathways with the potential to produce a range of biologically active secondary metabolites.

Funder

China Postdoctoral Science Foundation

Publisher

Frontiers Media SA

Subject

Ocean Engineering,Water Science and Technology,Aquatic Science,Global and Planetary Change,Oceanography

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Microbial Bioreactors;Microbial Bioreactors for Industrial Molecules;2023-06-09

2. New sesquiterpene from a soil fungus of Trichoderma sp;Natural Product Research;2022-12-19

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3