Glycerol Utilization Gene Cluster in Streptomyces clavuligerus-Reference-Cited by-同舟云学术

Glycerol Utilization Gene Cluster in Streptomyces clavuligerus

Published:2009-05 Issue:9 Volume:75 Page:2991-2995
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Baños Sonia¹,Pérez-Redondo Rosario¹²,Koekman Bert³,Liras Paloma¹²

Affiliation:

1. Área de Microbiología, Facultad de Ciencias Biológicas y Ambientales, Universidad de León, 24071 León, Spain

2. Instituto de Biotecnología, INBIOTEC, Parque Científico de León, 24006 León, Spain

3. DSM Anti-Infectives B.V., Delft, The Netherlands

Abstract

ABSTRACT The Streptomyces clavuligerus ATCC 27064 glycerol cluster gylR-glpF1K1D1 is induced by glycerol but is not affected by glucose. S. clavuligerus growth and clavulanic acid production are stimulated by glycerol, but this does not occur in a glpK1 -deleted mutant. Amplification of glpK1D1 results in transformants yielding larger amounts of clavulanic acid in the wild-type strain and in overproducer S. clavuligerus Gap15-7-30 or S. clavuligerus Δ relA strains.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00181-09

Reference19 articles.

1. Carbon Catabolite Regulation of Cephalosporin Production in Streptomyces clavuligerus

2. Aidoo, K. A., A. Wong, D. C. Alexander, R. A. Rittammer, and S. E. Jensen. 1994. Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis. Gene147:41-46.

3. In Silico and Transcriptional Analysis of Carbohydrate Uptake Systems of Streptomyces coelicolor A3(2)

4. Gomez-Escribano, J. P., J. F. Martín, A. Hesketh, M. J. Bibb, and P. Liras. 2008. Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp. Microbiology154:744-755.

5. Hindle, Z., and C. P. Smith. 1994. Substrate induction and catabolite repression of the Streptomyces coelicolor glycerol operon are mediated through the GylR protein. Mol. Microbiol.12:737-745.

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