Author:
Wang Xinyi,Long Youlin,Yang Liu,Huang Jin,Du Liang
Abstract
ObjectiveChildhood obesity is one of the most severe challenges of public health in the twenty-first century and may increase the risk of various physical and psychological diseases in adulthood. The prevalence and predictors of unreported results and premature termination in pediatric obesity research are not clear. We aimed to characterize childhood obesity trials registered on ClinicalTrials.gov and identify features associated with early termination and lack of results reporting.MethodsRecords were downloaded and screened for all childhood obesity trials from the inception of ClinicalTrials.gov to July 29, 2021. We performed descriptive analyses of characteristics, Cox regression for early termination, and logistic regression for lack of results reporting.ResultsWe identified 1,312 trials registered at ClinicalTrials.gov. Among clinicalTrials.gov registered childhood obesity-related intervention trials, trial unreported results were 88.5 and 4.3% of trials were prematurely terminated. Additionally, the factors that reduced the risk of unreported outcomes were US-registered clinical studies and drug intervention trials. Factors associated with a reduced risk of early termination are National Institutes of Health (NIH) or other federal agency funding and large trials.ConclusionThe problem of unreported results in clinical trials of childhood obesity is serious. Therefore, timely bulletin of the results and reasons for termination remain urgent aims for childhood obesity trials.
Funder
National Natural Science Foundation of China
Department of Science and Technology of Sichuan Province
Subject
Pediatrics, Perinatology and Child Health
Reference42 articles.
1. Effectiveness of a childhood obesity prevention programme delivered through schools, targeting 6 and 7 year olds: cluster randomised controlled trial (WAVES study);Adab;BMJ.,2018
2. Childhood obesity and the associated rise in cardiometabolic complications;Caprio;Nat Metabol.,2020
3. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013;Ng;Lancet.,2014
4. Childhood obesity: Aetiology, comorbidities, and treatment;Morales Camacho;Diabetes Metab Res Rev.,2019
5. The obese child in the Intensive Care Unit. Update;Donoso Fuentes;Arch Argent Pediatr.,2016
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