Author:
Barni Simona,Mori Francesca,Pecoraro Luca,Saretta Francesca,Giovannini Mattia,Arasi Stefania,Liotti Lucia,Mastrorilli Carla,Klain Angela,Gelsomino Mariannita,Castagnoli Riccardo,Miraglia del Giudice Michele,Novembre Elio
Abstract
Food protein-induced enteropathy (FPE) belongs to non-IgE gastrointestinal mediated food allergies. FPE is a syndrome characterized by diarrhea, weight loss and failure to thrive in young infants. Cow milk is the culprit food that most frequently causes FPE. The prevalence of FPE has not been fully estimated, but it is relatively rare. The diagnosis is based on the clinical manifestations and histological findings through colonoscopy. Laboratory tests are somewhat helpful in the diagnosis, although there are no disease-specific findings. Allergy testing for food specific IgE is not routinely recommended. The cornerstone of the management of FPE is the removal of culprit food from the diet. FPE is usually a transient condition that resolves in most cases by 1–2 years of life. This review addresses the latest findings on FPE, including a practical guide to assist pediatricians treating children with FPE.
Reference84 articles.
1. Non-IgE-mediated gastrointestinal food allergies in;Labrosse;Nutrients,2020
2. Protein-Losing enteropathy;Ozen;N Engl J Med,2023
3. Biopsy of the intestinal mucosa in children. Initial results of a study of the malabsorption syndromes;Lamy;Presse Med,1963
4. Malabsorption defect induced by ingestionof beta lactoglobulin;Davidson;J Pediatr,1965
5. Duodenal-jejunal histology in malabsorption syndrome in infants;Kuitunen;Ann Paediatr Fenn,1966