Author:
Zeng Qiaoli,Zou Dehua,Gu Shanshan,Han Fengqiong,Cao Shilin,Wei Yue,Guo Runmin
Abstract
Background:CDK5 regulatory subunit associated protein 1 like 1 (CDKAL1) is a major pathogenesis-related protein for type 2 diabetes mellitus (T2DM). Recently, some studies have investigated the association of CDKAL1 susceptibility variants, including rs4712523, rs4712524, and rs9460546 with T2DM. However, the results were inconsistent. This study aimed to evaluate the association of CDKAL1 variants and T2DM patients.Methods: A comprehensive meta-analysis was performed to assess the association between CDKAL1 SNPs and T2DM among dominant, recessive, additive, and allele models.Results: We investigated these three CDKAL1 variants to identify T2DM risk. Our findings were as follows: rs4712523 was associated with an increased risk of T2DM for the allele model (G vs A: OR = 1.172; 95% CI: 1.103–1.244; p < 0.001) and dominant model (GG + AG vs AA: OR = 1.464; 95% CI: 1.073–1.996; p = 0.016); rs4712524 was significantly associated with an increased risk of T2DM for the allele model (G vs A: OR = 1.146; 95% CI: 1.056–1.245; p = 0.001), additive model (GG vs AA: OR = 1.455; 95% CI: 1.265–1.673; p < 0.001) recessive model (GG vs AA + AG: OR = 1.343; 95% CI: 1.187–1.518; p < 0.001) and dominant model (GG + AG vs AA: OR = 1.221; 95% CI: 1.155–1.292; p < 0.001); and rs9460546 was associated with an increased risk of T2DM for the allele model (G vs T: OR = 1.215; 95% CI: 1.167–1.264; p = 0.023). The same results were found in the East Asian subgroup for the allele model.Conclusions: Our findings suggest that CDKAL1 polymorphisms (rs4712523, rs4712524, and rs9460546) are significantly associated with T2DM.
Subject
Genetics (clinical),Genetics,Molecular Medicine
Reference28 articles.
1. POLYMORPHIC VARIANTS rs4712524 AND rs6931514 IN THE CDKAL1 GENE: ASSOCIATION WITH THE RISK OF DEVELOPMENT OF TYPE 2 DIABETES MELLITUS IN RUSSIAN POPULATIONE;Azarova;Естественные и технические науки,2020
2. Identification of a Neuronal Cdk5 Activator-Binding Protein as Cdk5 Inhibitor;Ching;J. Biol. Chem.,2002
3. The Genetic Diversity Analysis of Candidate Genes Associated with Type 2 Diabetes in Xinjiang Ethnic Minority Populations;Gong,2016
4. Variants of thePPARG,IGF2BP2,CDKAL1,HHEX, andTCF7L2Genes Confer Risk of Type 2 Diabetes Independently of BMI in the German KORA Studies;Herder;Horm. Metab. Res.,2008
5. PPARG, KCNJ11, CDKAL1, CDKN2A-Cdkn2b, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 Are Associated with Type 2 Diabetes in a Chinese Population;Hu;PLoS One,2009
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献