Diagnostic and therapeutic strategies for non-alcoholic fatty liver disease

Author:

Fu Yajie,Zhou Yanzhi,Shen Linhu,Li Xuewen,Zhang Haorui,Cui Yeqi,Zhang Ke,Li Weiguo,Chen Wei-dong,Zhao Shizhen,Li Yunfu,Ye Wenling

Abstract

The global incidence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 25%. With the global increase in obesity and its associated metabolic syndromes, NAFLD has become an important cause of chronic liver disease in many countries. Despite recent advances in pathogenesis, diagnosis, and therapeutics, there are still challenges in its treatment. In this review, we briefly describe diagnostic methods, therapeutic targets, and drugs related to NAFLD. In particular, we focus on evaluating carbohydrate and lipid metabolism, lipotoxicity, cell death, inflammation, and fibrosis as potential therapeutic targets for NAFLD. We also summarized the clinical research progress in terms of drug development and combination therapy, thereby providing references for NAFLD drug development.

Publisher

Frontiers Media SA

Subject

Pharmacology (medical),Pharmacology

Reference175 articles.

1. Pathogenesis of insulin resistance and atherogenic dyslipidemia in nonalcoholic fatty liver disease;Akhtar;J. Clin. Transl. Hepatol.,2019

2. Review of galectin-3 inhibitors in the treatment of nonalcoholic steatohepatitis;Al Attar;Expert Rev. Clin. Pharmacol.,2021

3. Hepatic stearoyl CoA desaturase 1 deficiency increases glucose uptake in adipose tissue partially through the PGC-1α-FGF21 axis in mice;Aljohani;J. Biol. Chem.,2019

4. Effect of silymarin plus vitamin E in patients with non-alcoholic fatty liver disease. A randomized clinical pilot study;Aller;Eur. Rev. Med. Pharmacol. Sci.,2015

5. The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD;Angulo;Hepatology,2007

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