Congenital Infection Influence on Early Brain Development Through the Gut-Brain Axis

Author:

Kirschen Gregory W.,Panda Snigdha,Burd Irina

Abstract

The mechanisms by which various pathogens cause congenital infections have been studied extensively, aiding in the understanding of the detrimental effects these infections can have on fetal/neonatal neurological development. Recent studies have focused on the gut-brain axis as pivotal in neurodevelopment, with congenital infections causing substantial disruptions. There remains controversy surrounding the purported sterility of the placenta as well as concerns regarding the effects of exposure to antibiotics used during pregnancy on neonatal microbiome development and how early exposure to microbes or antibiotics can shape the gut-brain axis. Long-term neurodevelopmental consequences, such as autism spectrum disorder, attention deficit hyperactivity disorder, and cerebral palsy, may be attributable, in part, to early life infection and changes in the immature gut microbiome. The goal of this review is thus to critically evaluate the current evidence related to early life infection affecting neurodevelopment through the gut-brain axis.

Funder

National Institutes of Health

Publisher

Frontiers Media SA

Subject

General Neuroscience

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Treatment of preterm brain injury via gut‐microbiota–metabolite–brain axis;CNS Neuroscience & Therapeutics;2023-12-18

2. Neonatal Microbiome: Is it still Beneficial?;Endocrine, Metabolic & Immune Disorders - Drug Targets;2023-10-24

3. Gut Microbiome and Neurodevelopmental Disorders: A Link Yet to Be Disclosed;Microorganisms;2023-02-15

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