Author:
Richard Allison J.,Hang Hardy,Allerton Timothy D.,Zhao Peng,Mendoza Tamra,Ghosh Sujoy,Elks Carrie M.,Stephens Jacqueline M.
Abstract
STATs (Signal Transducers and Activators of Transcription) 5A and 5B are induced during adipocyte differentiation and are primarily activated by growth hormone (GH) and prolactin in fat cells. Previous studies in mice lacking adipocyte GH receptor or STAT5 support their roles in lipolysis-mediated reduction of adipose tissue mass. Male and female mice harboring adipocyte-specific deletion of both STAT5 genes (STAT5AKO) exhibit increased subcutaneous or inguinal adipose tissue mass, but no changes in visceral or gonadal fat mass. Both depots display substantial increases in adipocyte size with no changes in lipolysis in adipose tissue explants. RNA sequencing analysis of subcutaneous adipose tissue and indirect calorimetry experiments reveal sex-dependent differences in adipose gene expression and whole-body energy expenditure, respectively, resulting from the loss of adipocyte STAT5.
Funder
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health
Subject
Endocrinology, Diabetes and Metabolism
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