Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction-Reference-Cited by-同舟云学术

Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction

Published:2023-11-01 Issue:5 Volume:325 Page:E438-E447
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Harvey Innocence¹^ORCID,Richard Allison J.¹^ORCID,Mendoza Tamra M.¹^ORCID,Stephens Jacqueline M.¹²^ORCID

Affiliation:

1. Adipocyte Biology Department, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States

2. Biological Sciences Department, Louisiana State University, Baton Rouge, Louisiana, United States

Abstract

Both STAT5 and glucocorticoid receptor contribute to metabolic processes and type 2 diabetes, in large part, due to their functions in adipocytes. These two transcription factors can form a complex and function together. Our novel studies determined the role of adipocyte STAT5 in glucocorticoid-induced diabetes. We observed that STAT5 in adipocytes is not needed for glucocorticoid-induced diabetes.

Funder

COBRE

NORC

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00116.2023

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