Author:
Agrati Chiara,Di Cosimo Serena,Fenoglio Daniela,Apolone Giovanni,Ciceri Fabio,Ciliberto Gennaro,Baldanti Fausto,Costantini Massimo,Giannarelli Diana,Ippolito Giuseppe,Locatelli Franco,Mantovani Alberto,Morrone Aldo,Tagliavini Fabrizio,Uccelli Antonio,Zinzani Pier Luigi,Silvestris Nicola,Rescigno Maria
Abstract
Patients diagnosed with malignancy, neurological and immunological disorders, i.e., fragile patients, have been excluded from COVID-19 vaccine trials. However, this population may present immune response abnormalities, and relative reduced vaccine responsiveness. Here we review the limited current evidence on the immune responses to vaccination of patients with different underlying diseases. To address open questions we present the VAX4FRAIL study aimed at assessing immune responses to vaccination in a large transdisease cohort of patients with cancer, neurological and rheumatological diseases.
Subject
Immunology,Immunology and Allergy
Cited by
21 articles.
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