Author:
Ryan Grace E.,Harris John E.,Richmond Jillian M.
Abstract
Tissue resident memory T cells (TRM) are a critical component of the immune system, providing the body with an immediate and highly specific response against pathogens re-infecting peripheral tissues. More recently, however, it has been demonstrated that TRM cells also form during autoimmunity. TRM mediated autoimmune diseases are particularly destructive, because unlike foreign antigens, the self-antigens are never cleared, continuously activating self-reactive TRM T cells. In this article, we will focus on how TRMs mediate disease in autoimmune skin conditions, specifically vitiligo, psoriasis, cutaneous lupus erythematosus, alopecia areata and frontal fibrosing alopecia.
Funder
Dermatology Foundation
Lupus Research Alliance
National Institutes of Health
U.S. Department of Defense
Subject
Immunology,Immunology and Allergy
Cited by
42 articles.
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