Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo-Reference-Cited by-同舟云学术

Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo

Published:2018-07-18 Issue:450 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Richmond Jillian M.¹^ORCID,Strassner James P.¹,Zapata Lucio¹^ORCID,Garg Madhuri¹,Riding Rebecca L.¹,Refat Maggi A.¹,Fan Xueli¹,Azzolino Vincent¹,Tovar-Garza Andrea²^ORCID,Tsurushita Naoya³,Pandya Amit G.²,Tso J. Yun³,Harris John E.¹^ORCID

Affiliation:

1. Department of Dermatology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

2. University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

3. JN Biosciences LLC, Mountain View, CA 94043, USA.

Abstract

Human and mouse resident memory T cells are present in vitiligo lesions, and blocking IL-15 signaling provides long-lasting reversal of disease in a mouse model of vitiligo.

Funder

National Institutes of Health

Dermatology Foundation

American Skin Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

1. Autoimmune Destruction of Skin Melanocytes by Perilesional T Cells from Vitiligo Patients

2. Vitiligo: A comprehensive overview

3. Vitiligo: A comprehensive overview