Author:
Jiang Lin,Tang Ao,Song Lihua,Tong Yigang,Fan Huahao
Abstract
Rotavirus (RV) causes 200,000 deaths per year and imposes a serious burden to public health and livestock farming worldwide. Currently, rehydration (oral and intravenous) remains the main strategy for the treatment of rotavirus gastroenteritis (RVGE), and no specific drugs are available. This review discusses the viral replication cycle in detail and outlines possible therapeutic approaches including immunotherapy, probiotic-assisted therapy, anti-enteric secretory drugs, Chinese medicine, and natural compounds. We present the latest advances in the field of rotavirus antivirals and highlights the potential use of Chinese medicine and natural compounds as therapeutic agents. This review provides an important reference for rotavirus prevention and treatment.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Beijing University of Chemical Technology
Fundamental Research Funds for the Central Universities
Subject
Immunology,Immunology and Allergy
Cited by
5 articles.
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