Global Review of the Age Distribution of Rotavirus Disease in Children Aged <5 Years Before the Introduction of Rotavirus Vaccination
Author:
Hasso-Agopsowicz Mateusz12ORCID, Ladva Chandresh Nanji3, Lopman Benjamin3, Sanderson Colin1, Cohen Adam L2, Tate Jacqueline E4, Riveros Ximena2, Henao-Restrepo Ana Maria2, Clark Andrew1, Alkorta M, Atchison C, Banajeh S, Becker-Dreps S, Benhafid M, Bhandari N, Bodhidatta L, Braeckman T, Bwogi J, de Cassia Compagnoli Carmona R, Cilla G, Contreras-Roldan I, Coulson B, Cunliffe N A, Dagan R, Givon N, Degiuseppe J I, Dhiman S, Dian Z, Diaz J, Dutta S, Krishnan T, Manna B, Fletcher-Lartey S, Fu C, Gendrel D, Ghenghesh K S, Gonzalez Mago G, De Grazia S, Grimwood K, Groome M, Haque A, Heininger U, Houpt E R, Iturriza-Gomara M, Hungerford D, Jarquin C M, McCracken J P, Contreras I L, Cordon-Rosales C, Kaiser-Labusch P, Kang G, Kar S, Kiulia N, Kotloff K, Latipov R, Linhares A, Lorrot M, Mandile M, Mast C, Mathew M A, Matinon-Torres F, Matthijnssens J, Mladenova Z, Monini M, Montes M, Arana A, Motamedifar M, Najafi A, Nelson T, Nokes J, Ntoumi F, Numazaki K, O’Reilly C, Ochoa T J, Page N A, Page A L, Langendorf C, Podkolzin A T, Quach C, Racz M L, de Rougemont A, Ruiz-Palacios G M, Saha S K, Saha S, Satter S M, Soares L, Sudarmo S M, Shigemura K, Shirakawa T, Athiyyah A F, Tagbo B, Tarr P, Klein E, Denno D M, Turner A, Uzoma E B, Vatosoa R R, Wandera E A, Wikswo M, Payne D, Yhu-Chering H, Yoshikawa T, Sugata K, Yuan Q, Liying L, Zaman K, Zhou X -N, Zhang S -X, Xu W, Serhan Fatima, Nakamura Tomoka, Antoni Sébastien, Agócs Mary, Murray Jillian, Cherian Thomas, Mwenda Jason M, Weldegebriel Goitom, Biey Joseph N M, Cheikh Dah, Teleb Nadia, Rahman Hossam Abdel, Ahmed Hinda, Daniels Danni, Videbaek Dovile, Wasley Annemarie, Singh Simarjit, de Oliveira Lucia, Rey-Benito Gloria, Sanwogou N Jennifer, Liyanage Jayantha, Wijesinghe Pushpa Ranjan, Batmunkh Nyambat, Grabovac Varja, Fox Kimberley, Paladin Fem Julia, Henschke Nicholas,
Affiliation:
1. London School of Hygiene and Tropical Medicine, United Kingdom 2. World Health Organization, Geneva, Switzerland 3. Emory University, Atlanta, Georgia 4. Centers for Disease Control and Prevention, Atlanta, Georgia
Abstract
Abstract
We sought datasets with granular age distributions of rotavirus-positive disease presentations among children <5 years of age, before the introduction of rotavirus vaccines. We identified 117 datasets and fit parametric age distributions to each country dataset and mortality stratum. We calculated the median age and the cumulative proportion of rotavirus gastroenteritis events expected to occur at ages between birth and 5.0 years. The median age of rotavirus-positive hospital admissions was 38 weeks (interquartile range [IQR], 25–58 weeks) in countries with very high child mortality and 65 weeks (IQR, 40–107 weeks) in countries with very low or low child mortality. In countries with very high child mortality, 69% of rotavirus-positive admissions in children <5 years of age were in the first year of life, with 3% by 10 weeks, 8% by 15 weeks, and 27% by 26 weeks. This information is critical for assessing the potential benefits of alternative rotavirus vaccination schedules in different countries and for monitoring program impact.
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Microbiology (medical)
Cited by
36 articles.
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