Author:
Chen Yan,Wang Guisheng,Yuan Yilin,Zou Ge,Yang Wencong,Tan Qi,Kang Wenyi,She Zhigang
Abstract
Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E (1) and F (2), one new chromone fusarimone A (5), two new benzofurans fusarifurans A (9) and B (10), three new isocoumarins fusarimarins A–C (11–13), as well as five known analogues 3, 4, 6–8 and 14 were isolated from mangrove endophytic fungus Fusarium sp. 2ST2. Their structures and absolute configurations were established by spectroscopic analysis, density functional theory-gauge invariant atomic orbital NMR calculation with DP4+ statistical analysis, and electronic circular dichroism calculation. Compounds 1 and 2 showed significant cytotoxicity against human A549 cell lines with IC50 values of 8.7 and 4.3 μM, respectively.
Funder
National Natural Science Foundation of China
Special Project for Research and Development in Key Areas of Guangdong Province
Key Scientific Research Project of Colleges and Universities in Henan Province
Henan Provincial Science and Technology Research Project
Cited by
11 articles.
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