Author:
Zhang Yongqing,Zhou Yihui,Fang Wen,Zhu Hanlin,Ye Cunqi,Zhang Delong,Lee Hyeon Jeong
Abstract
Graphical AbstractHigh-resolution stimulated Raman scattering (SRS) imaging of a genetically engineered model (GEM) enables metabolite imaging in a yeast model and uncovers an unexpected regulatory mechanism of sterol metabolism, providing new insights underpinning the distributional and functional importance of sterol in cells. SRS-GEM demonstrates a promising platform to explore unknown metabolic mechanisms beyond the reach of conventional approaches.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities