Mean-field based framework for forward modeling of LFP and MEG signals

Abstract

The use of mean-field models to describe the activity of large neuronal populations has become a very powerful tool for large-scale or whole brain simulations. However, the calculation of brain signals from mean-field models, such as the electric and magnetic fields, is still under development. Thus, the emergence of new methods for an accurate and efficient calculation of such brain signals is currently of great relevance. In this paper we propose a novel method to calculate the local field potentials (LFP) and magnetic fields from mean-field models. The calculation of LFP is done via a kernel method based on unitary LFP's (the LFP generated by a single axon) that was recently introduced for spiking-networks simulations and that we adapt here for mean-field models. The calculation of the magnetic field is based on current-dipole and volume-conductor models, where the secondary currents (due to the conducting extracellular medium) are estimated using the LFP calculated via the kernel method and the effects of medium-inhomogeneities are incorporated. We provide an example of the application of our method for the calculation of LFP and MEG under slow-waves of neuronal activity generated by a mean-field model of a network of Adaptive-Exponential Integrate-and-Fire (AdEx) neurons. We validate our method via comparison with results obtained from the corresponding spiking neuronal networks. Finally we provide an example of our method for whole brain simulations performed with The Virtual Brain (TVB), a recently developed tool for large scale simulations of the brain. Our method provides an efficient way of calculating electric and magnetic fields from mean-field models. This method exhibits a great potential for its application in large-scale or whole-brain simulations, where calculations via detailed biological models are not feasible.