Author:
Zhanghuang Chenghao,Chen Shuo,Li Li,Yang Zhen,Xie Yucheng,Li Jiwei,Tang Haoyu,He Xiaoli,Dong Liuyi,Yan Bing
Abstract
BackgroundMalignant rhabdoid tumor of the kidney (MRTK) is a rare type of tumor that lacks typical clinical manifestations. Herein, we presented clinical data of 2 children with MRTK. In addition, we used a high-throughput RNA-sequencing (RNA-seq), GO analysis, and KEGG signaling pathway analysis to examine gene expression differences at the transcripts level between 2 patients with MRTK and 3 patients with non-tumor diseases without other symptoms.Case reportPreoperative B-scan ultrasonography and computed tomography (CT) examination in 2 cases suggested nephroblastoma. Both patients were treated with radical nephrectomy. After the operation, MRTK was confirmed by pathological examination. Child 1 and Child 2 then received 7 courses and 12 courses of regular chemotherapy, respectively. Child 1 was followed up for 2 years, and Child 2 for 3.1 years without showing symptoms. RNA-seq results showed 2203 differential genes (DEGs) in the kidney tissue of children with MRTK compared to normal tissue (p <0.01). GO analysis suggested that most DEGs participate in protein binding. KEGG results showed that the DEGs were mainly involved in the PI3K-Akt signaling pathway and microRNA-related proteins.ConclusionThe PI3K-Akt signaling pathway and microRNA-related proteins as targets have extremely high potential value for the diagnosis and treatment of MRTK.
Reference31 articles.
1. Current Situation and Prospect of Treatment of Malignant Rhabdomyoid Tumor in Children;Wang;Chin J Pediatr Blood Cancer,2018
2. Advances in the study of malignant rhabdomyoid tumors in children;Cai;Int J Blood Transfusion Hematol,2016
3. Clinical and prognostic features of renal malignant rhabdomyosarcoma in 35 children;Cheng;Chin J Pediatr Blood Cancer,2018
4. Malignant Rhabdoid Tumor of the Kidney (MRTK) – Data of 52 Patients Treated According to Protocols of the GPOH (German Society of Paediatric Oncology and Haematology);Furtwängler;Cancer Genet,2014
5. Histopathology and prognosis of Wilms tumors: results from the First National Wilms’ Tumor Study;Beckwith;Cancer,1978
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献