Clinical and Molecular Differentiation Between Malignant Rhabdoid Tumor of the Kidney and Normal Tissue: A Two-Case Report

Author:

Zhanghuang Chenghao,Chen Shuo,Li Li,Yang Zhen,Xie Yucheng,Li Jiwei,Tang Haoyu,He Xiaoli,Dong Liuyi,Yan Bing

Abstract

BackgroundMalignant rhabdoid tumor of the kidney (MRTK) is a rare type of tumor that lacks typical clinical manifestations. Herein, we presented clinical data of 2 children with MRTK. In addition, we used a high-throughput RNA-sequencing (RNA-seq), GO analysis, and KEGG signaling pathway analysis to examine gene expression differences at the transcripts level between 2 patients with MRTK and 3 patients with non-tumor diseases without other symptoms.Case reportPreoperative B-scan ultrasonography and computed tomography (CT) examination in 2 cases suggested nephroblastoma. Both patients were treated with radical nephrectomy. After the operation, MRTK was confirmed by pathological examination. Child 1 and Child 2 then received 7 courses and 12 courses of regular chemotherapy, respectively. Child 1 was followed up for 2 years, and Child 2 for 3.1 years without showing symptoms. RNA-seq results showed 2203 differential genes (DEGs) in the kidney tissue of children with MRTK compared to normal tissue (p <0.01). GO analysis suggested that most DEGs participate in protein binding. KEGG results showed that the DEGs were mainly involved in the PI3K-Akt signaling pathway and microRNA-related proteins.ConclusionThe PI3K-Akt signaling pathway and microRNA-related proteins as targets have extremely high potential value for the diagnosis and treatment of MRTK.

Publisher

Frontiers Media SA

Subject

Cancer Research,Oncology

Reference31 articles.

1. Current Situation and Prospect of Treatment of Malignant Rhabdomyoid Tumor in Children;Wang;Chin J Pediatr Blood Cancer,2018

2. Advances in the study of malignant rhabdomyoid tumors in children;Cai;Int J Blood Transfusion Hematol,2016

3. Clinical and prognostic features of renal malignant rhabdomyosarcoma in 35 children;Cheng;Chin J Pediatr Blood Cancer,2018

4. Malignant Rhabdoid Tumor of the Kidney (MRTK) – Data of 52 Patients Treated According to Protocols of the GPOH (German Society of Paediatric Oncology and Haematology);Furtwängler;Cancer Genet,2014

5. Histopathology and prognosis of Wilms tumors: results from the First National Wilms’ Tumor Study;Beckwith;Cancer,1978

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3