Author:
Zhanghuang Chenghao,Zhang Zhaoxia,Zeng Li,Yan Bing,Tang Haoyu,Wang Jinkui,Liu Xing,Wei Guanghui,He Dawei
Abstract
Abstract
Objective
To discuss the clinical and prognostic indicators of pediatric malignant rhabdoid tumor of the kidney (MRTK), and to increase the understanding of the occurrence and development of MRTK.
Methods
From July 2014 to September 2021, all cases were confirmed by postoperative pathological examination. Among the 42 patients, there were 25 males and 17 females, with a median age of 10 (1–84) months. Abdominal mass or hematuria were the main clinical manifestations. Preoperative chemotherapy was performed in 9 cases (VC). The tumor stages were stage I-IV. Preoperative metastasis was found in 9 cases; the most common site was the lung. Postoperative patients received conventional chemotherapy, including VDACE regimen and UH-1 regimen. Among the 42 children in this group, survival at follow-up in this study was 26.2%(11/42).
Results
Preoperative anemia was found by univariate analysis, hypertension and hypercalcemia had shorter survival time. In addition, tumor-related factors had a significant impact on survival, with incomplete tumor resection, lymph node metastasis, stage III-IV had a lower survival rate. The impact of postoperative factors on survival included postoperative complications had a lower survival rate. The children were younger than 12 months, preoperative metastasis, no chemotherapy was performed after surgery was an independent risk factor for the prognosis of MRTK.
Conclusion
The main clinical manifestations about MRTK were abdominal mass and hematuria. Preoperative chemotherapy did not significantly improve the prognosis. Postoperative chemotherapy can significantly improve the survival rate. Diagnosis depends on clinical manifestations, imaging, histopathology, immunohistochemistry and other comprehensive judgment. Age less than 12 months, preoperative metastasis, and no postoperative chemotherapy were independent risk factors for prognosis.
Funder
Yunnan Education Department of Science Research Fund
Kunming City Health Science and Technology Talent “1000” training Project
Kunming Health and Health Commission Health Research Project
Open research fund of Children’s Health and Disease Clinical Medical Research Center of Yunnan Province
Kunming Medical Joint Project of Yunnan Science and Technology Department
Chongqing Talent Program“lump sum project”
Special Key Project of Chongqing Technology Innovation and Application Development
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health
Cited by
1 articles.
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