Author:
Qiu Dan,Zhang Guijuan,Yan Xianxin,Xiao Xinqin,Ma Xinyi,Lin Shujun,Wu Jieyan,Li Xinyuan,Wang Wandi,Liu Junchen,Ma Yi,Ma Min
Abstract
In the classification and typing of breast cancer, triple-negative breast cancer (TNBC) is one type of refractory breast cancer, while chemotherapy stays in the traditional treatment methods. However, the impact of chemotherapy is short-lived and may lead to recurrence due to incomplete killing of tumor cells. The occurrence, development, and relapse of breast cancer are relevant to T cell dysfunction, multiplied expression of related immune checkpoint molecules (ICIs) such as programmed death receptor 1 (PD-1), programmed cell death 1 ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) produce immunosuppressive effect. Immunotherapy (namely, immune checkpoint inhibitors, adoptive cellular immunotherapy, CAR-T immunotherapy and some potential treatments) provides new hope in TNBC. This review focuses on the new immune strategies of TNBC patients.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangdong Province
Cited by
17 articles.
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