Insights Into the Function and Clinical Application of HDAC5 in Cancer Management-Reference-Cited by-同舟云学术

Insights Into the Function and Clinical Application of HDAC5 in Cancer Management

Published:2021-06-10 Issue: Volume:11 Page:
ISSN:2234-943X
Container-title:Frontiers in Oncology
language:
Short-container-title:Front. Oncol.

Author:

Yang Jun,Gong Chaoju,Ke Qinjian,Fang Zejun,Chen Xiaowen,Ye Ming,Xu Xi

Abstract

Histone deacetylase 5 (HDAC5) is a class II HDAC. Aberrant expression of HDAC5 has been observed in multiple cancer types, and its functions in cell proliferation and invasion, the immune response, and maintenance of stemness have been widely studied. HDAC5 is considered as a reliable therapeutic target for anticancer drugs. In light of recent findings regarding the role of epigenetic reprogramming in tumorigenesis, in this review, we provide an overview of the expression, biological functions, regulatory mechanisms, and clinical significance of HDAC5 in cancer.

Funder

Natural Science Foundation of Zhejiang Province

Medical and Health Research Project of Zhejiang Province

Science and Technology Plan Project of Taizhou

Publisher

Frontiers Media SA

Subject

Cancer Research,Oncology

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