Author:
Nishiyama Akihiro,Sato Shigeki,Sakaguchi Hiroyuki,Kotani Hiroshi,Yamashita Kaname,Ohtsubo Koushiro,Nanjo Shigeki,Yano Seiji,Mizuguchi Keishi,Ikeda Hiroko,Takeuchi Shinji
Abstract
We report a case of limited effectiveness of dabrafenib and trametinib in a 59-year-old man with poorly differentiated lung carcinoma and a rare BRAF K601E mutation. The patient, unresponsive to chemotherapy and immunotherapy, received these targeted agents as second-line treatment. Despite a notable initial response, tumor regression lasted only 52 days. A subsequent liquid biopsy revealed additional alterations (BRAF amplification, KIT amplification, TP53 S241F), indicating a complex resistance mechanism. This case underscores the challenges in treating BRAF K601E-mutant lung carcinoma, emphasizing the need for advanced molecular diagnostics, personalized approaches, and further research into more effective therapies for unique genetic profiles.