An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling-Reference-Cited by-同舟云学术

An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling

Published:2016-09 Issue:3 Volume:30 Page:485-498
ISSN:1535-6108
Container-title:Cancer Cell
language:en
Short-container-title:Cancer Cell

Author:

Karoulia Zoi,Wu Yang,Ahmed Tamer A.,Xin Qisheng,Bollard Julien,Krepler Clemens,Wu Xuewei,Zhang Chao,Bollag Gideon,Herlyn Meenhard,Fagin James A.,Lujambio Amaia,Gavathiotis Evripidis,Poulikakos Poulikos I.

Funder

NIH

Sidney Kimmel Foundation for Cancer Research

Gabrielle's Angels Foundation for Cancer Research

Alexandrine and Alexander L. Sinsheimer Foundation

Publisher

Elsevier BV

Subject

Cancer Research,Cell Biology,Oncology

Reference46 articles.

1. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma;Bollag;Nature,2010

2. Improved survival with vemurafenib in melanoma with BRAF V600E mutation;Chapman;N. Engl. J. Med.,2011

3. Oncogenic BRAF deletions that function as homodimers and are sensitive to inhibition by RAF dimer inhibitor LY3009120;Chen;Cancer Discov.,2016

4. Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers;Corcoran;Oncotarget,2011

5. EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib;Corcoran;Cancer Discov.,2012

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