Rice stripe virus p2 protein interacts with ATG5 and is targeted for degradation by autophagy

Author:

Zhang Xiangxiang,Wan Qionglian,Rui Penghuan,Lu Yuwen,Sun Zongtao,Chen Jianping,Wang Yunyue,Yan Fei

Abstract

Autophagy can be induced by viral infection and plays antiviral roles in plants, but the underlying mechanism is not well understood. In our previous reports, we have demonstrated that the plant ATG5 plays an essential role in activating autophagy in rice stripe virus (RSV)-infected plants. We also showed that eIF4A, a negative factor of autophagy, interacts with and inhibits ATG5. We here found that RSV p2 protein interacts with ATG5 and can be targeted by autophagy for degradation. Expression of p2 protein induced autophagy and p2 protein was shown to interfere with the interaction between ATG5 and eIF4A, while eIF4A had no effect on the interaction between ATG5 and p2. These results indicate an additional information on the induction of autophagy in RSV-infected plants.

Funder

National Natural Science Foundation of China

Publisher

Frontiers Media SA

Subject

Microbiology (medical),Microbiology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Plant virology in the 21st century in China: Recent advances and future directions;Journal of Integrative Plant Biology;2024-01-02

2. The Great Game between Plants and Viruses: A Focus on Protein Homeostasis;International Journal of Molecular Sciences;2023-08-09

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