Author:
Wang Zhenhui,Li Zhanlin,Niu Chao,Yang Lanping,Zhai Yangyang,Li Dehai,Wu Guangwei,Zhang Zhenzhen,He Xueqian
Abstract
Introduction and MethodsSilencing gene activation can effectively enrich the diversity of fungal secondary metabolites.Results and DiscussionCultivation of the Yellow River wetland-derived fungus Talaromyces funiculosus HPU-Y01 with aniline led to the isolation of one new aniline-containing polyketide tanicutone A (1), two new bicyclic polyketides tanicutones B-C (2–3), a new related trienoic acid 8-methyldeca-2,4,6-trienoic acid (5), and a known compound 4. The planar structures and configurations of 1–5 were determined by NMR, MS, and ECD calculations. Compound 2 featured a key aldehyde group and showed promising inhibitory activity against Vibrio parahaemolyticus with a minimum inhibitory concentration (MIC) value of 0.17 μg/mL. This is a rare report of aniline-induced fungal production of tetrahydronaphthone polyketides.
Funder
National Natural Science Foundation of China
Henan Polytechnic University
Subject
Microbiology (medical),Microbiology
Cited by
1 articles.
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