Nationwide analysis of antimicrobial resistance in pathogenic Escherichia coli strains isolated from diseased swine over 29 years in Japan

Author:

Kusumoto Masahiro,Tamamura-Andoh Yukino,Hikoda-Kogiku Yuna,Magome Asami,Okuhama Erina,Sato Keisuke,Mizuno Yoshino,Arai Nobuo,Watanabe-Yanai Ayako,Iwata Taketoshi,Ogura Yoshitoshi,Gotoh Yasuhiro,Nakamura Keiji,Hayashi Tetsuya,Akiba Masato

Abstract

Pathogenic Escherichia coli strains are important causes of several swine diseases that result in significant economic losses worldwide. In Japan, the use of antimicrobials in swine is much higher than that in other farm animals every year. Antimicrobial resistance in pathogenic E. coli strains also heavily impacts the swine industry due to the limited treatment options and an increase in the potential risk of the One Health crisis. In 2016, we investigated 684 Japanese isolates of swine pathogenic E. coli belonging to four major serogroups and reported the emergence and increase in the highly multidrug-resistant serogroups O116 and OSB9 and the appearance of colistin-resistant strains. In the present study, by expanding our previous analysis, we determined the serotypes and antimicrobial resistance of 1,708 E. coli strains isolated from diseased swine between 1991 and 2019 in Japan and found recent increases in the prevalences of multidrug-resistant strains and minor serogroup strains. Among the antimicrobials examined in this study that have been approved for animal use, a third-generation cephalosporin was found to be effective against the most isolates (resistance rate: 1.2%) but not against highly multidrug-resistant strains. We also analyzed the susceptibilities of the 1,708 isolates to apramycin and bicozamycin, both which are available for treating swine in Japan, and found that the rates of resistance to apramycin and bicozamycin were low (6.7% and 5.8%, respectively), and both antimicrobials are more effective (resistance rates: 2.7% and 5.4%, respectively) than third-generation cephalosporins (resistance rate: 16.2%) against highly multidrug-resistant strains.

Funder

Ministry of Agriculture, Forestry and Fisheries

Japan Society for the Promotion of Science

Publisher

Frontiers Media SA

Subject

Microbiology (medical),Microbiology

Reference41 articles.

1. Bacterial pathogens of pigs with particular reference to Escherichia coli: a systematic review and meta-analysis.;Abubakar;J. Vet. Med. Anim. Health,2017

2. Cloning and sequence analysis of an Escherichia coli gene conferring bicyclomycin resistance.;Bentley;Gene,1993

3. Epidemiology of beta-lactamase-producing pathogens.;Bush;Clin. Microbiol. Rev.,2020

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