Author:
McMahon Meagan,Ye Siying,Pedrina Jess,Dlugolenski Daniel,Stambas John
Abstract
Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (ADAMTS) play a vital role in pathogen defence and have been shown to influence migration of immune cells. This review provides a current summary of the role of ECM enzymes in immune cell migration and function and discusses opportunities and limitations for development of diagnostic and therapeutic strategies targeting metalloproteinase expression and activity in the context of infectious disease.
Funder
National Health and Medical Research Council
Subject
Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry
Reference106 articles.
1. Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family;Abbaszade;J. Biol. Chem.,1999
2. Gelatinases (MMP-2 and MMP-9) Are Preferentially Expressed by Th1 vs. Th2 Cells;Abraham;J. Neuroimmunol,2005
3. The In Vitro Activity of ADAM-10 Is Inhibited by TIMP-1 and TIMP-3;Amour;FEBS Lett.,2000
4. Elastin‐Elastases and Inflamm‐Aging;Antonicelli;Curr. Top. Dev. Biol.,2007
5. In Vitro migration of Lymphocytes through Collagen Matrix: Arrested Locomotion in Tumor-Infiltrating Lymphocytes;Applegate;Cancer Res.,1990
Cited by
32 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献