Northienamycin and 8-epi-thienamycin, new carbapenems from Streptomyces cattleya.
Author:
Publisher
Japan Antibiotics Research Association
Subject
Drug Discovery,Pharmacology
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1. ThnL, a B12-dependent radical S -adenosylmethionine enzyme, catalyzes thioether bond formation in carbapenem biosynthesis;Proceedings of the National Academy of Sciences;2022-08-15
2. C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation;mBio;2022-06-28
3. Base Induced Condensation of Malononitrile with Erlenmeyer Azlactones: An Unexpected Synthesis of Multi‐Substituted Δ 2 ‐Pyrrolines and Their Cytotoxicity;Chemistry & Biodiversity;2020-04-16
4. Methylations in complex carbapenem biosynthesis are catalyzed by a single cobalamin-dependent radicalS-adenosylmethionine enzyme;Chemical Communications;2019
5. Metabolic engineering of a carbapenem antibiotic synthesis pathway in Escherichia coli;Nature Chemical Biology;2018-06-25
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