Abstract
A simple and highly efficient protocol for the synthesis of derivatives 7, 7-dimethyl-4-phenyl-2-thioxo-2, 3, 4, 6, 7, 8-hexahydro-1H-quinazoline-5-one from 5, 5-dimethyl cyclohexane-1, 3-dione (4a–4h) (dimedone) has been described. The aryl aldehydes were substituted with thiourea in the presence of synthesized zinc ferrite nanocatalyst, which increased the yield under reflux through condensation, followed by cyclization to give desired products. The other advantages are that it is eco-friendly and economically affordable for large-scale production. Structural validation and characterization of all the newly synthesized compounds were evaluated by spectral analysis (mass spectrometry, proton nuclear magnetic resonance (1HNMR), and Carbon-13 nuclear magnetic resonance(13CNMR)spectroscopies. The structure of antibacterial and antifungal assays was performed with the newly synthesized compounds. The antimicrobial activity of title compounds possessing electron-withdrawing groups such as (4e–4h) (Cl, Br, and cyano group) exhibited more active potential than the electron-donating groups, C6H5,4-C6H4, 3-OC2H5-4OH-C6H3, etc., (4a–4d) containing moiety.
Subject
Physical and Theoretical Chemistry,Catalysis
Reference37 articles.
1. The Organic Chemistry of Drug Synthesis;Lednicer,1977
2. The Organic Chemistry of Drug Synthesis;Lednicer,1980
3. Synthesis and CNS depressant activity of some derivatives of novel 3-[5-substituted-1, 3,4-thiadiazole-2-yl]-2-styrylquinazolin-4-(3H)-one;Kershaw;Eur. J. Med. Chem.,2008
4. Synthesis of heterocycles having double character: As antimicrobial;Sayed;J. Chinesechem. Soc.,2005
5. Synthesis of 3-monosubstitutedquinazolin-4-(3H)-ones;Tyagi;Ind. J. Chem.,1995
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献