Affiliation:
1. N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia
Abstract
In recent years, the application of privileged structures has become a powerful approach in the discovery of new biologically active molecules. Ion pairing is a strategy used to enhance the permeation of ionized topical drugs. A convenient and efficient method for the synthesis of triethylammonium 2-(3-hydroxy-2-oxoindolin-3-yl)-5,5-dimethyl-3-oxocyclohex-1-en-1-olate has been developed. The presented protocol includes an aldol reaction and the formation of an ammonium salt. Triethylamine is both a reactant and a catalyst in the process. The structure of the synthesized title compound has been established by 1H, 13C-NMR and IR spectroscopy, mass spectrometry, and elemental analysis.
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Reference27 articles.
1. The Rise and Fall of a Scaffold: A Trend Analysis of Scaffolds in the Medicinal Chemistry Literature;Zdrazil;J. Med. Chem.,2018
2. Privileged scaffolds in lead generation;Zhao;Expert Opin. Drug Discov.,2015
3. Methods for drug discovery: Development of potent, selective, orally effective cholecystokinin antagonists;Evans;J. Med. Chem.,1988
4. Skoreński, M., and Sieńczyk, M. (2021). The Fellowship of Privileged Scaffolds—One Structure to Inhibit Them All. Pharmaceuticals, 14.
5. Synthesis and Biological Evaluation of Novel 4,5,6,7-Tetrahydrobenzo[D]-Thiazol-2-Yl Derivatives Derived from Dimedone with Anti-Tumor, C-Met, Tyrosine Kinase and Pim-1 Inhibitions;Mohareb;Anticancer Agents Med. Chem.,2019
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