Precision Medicine Is Changing the Roles of Healthcare Professionals, Scientists, and Research Staff: Learnings from a Childhood Cancer Precision Medicine Trial

Author:

Daly Rebecca12ORCID,Hetherington Kate12ORCID,Hazell Emily123,Wadling Bethany R.123,Tyrrell Vanessa14,Tucker Katherine M.56,Marshall Glenn M.147,Ziegler David S.147ORCID,Lau Loretta M. S.147ORCID,Trahair Toby N.147ORCID,O’Brien Tracey A.147,Collins Kiri4,Gifford Andrew J.148,Haber Michelle4,Pinese Mark14,Malkin David9,Cowley Mark J.1410ORCID,Karpelowsky Jonathan111213,Drew Donna7,Jacobs Chris3ORCID,Wakefield Claire E.12ORCID

Affiliation:

1. Discipline of Pediatrics and Child Health, School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW 2052, Australia

2. Behavioural Sciences Unit, Kids Cancer Centre, Sydney Children’s Hospital, Randwick, NSW 2031, Australia

3. Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia

4. Children’s Cancer Institute, UNSW Sydney, Sydney, NSW 2052, Australia

5. Hereditary Cancer Centre, Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW 2031, Australia

6. Prince of Wales Clinical School, UNSW Sydney, Randwick, NSW 2031, Australia

7. Kids Cancer Centre, Sydney Children’s Hospital, Randwick, NSW 2031, Australia

8. Anatomical Pathology, NSW Health Pathology, Prince of Wales Hospital, Randwick, NSW 2031, Australia

9. Division of Haematology/Oncology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada

10. Kinghorn Centre for Clinical Genomics, Garvan Institute, Darlinghurst, NSW 2010, Australia

11. Department of Paediatric Surgery, Children’s Hospital at Westmead, Westmead, NSW 2145, Australia

12. Children’s Cancer Research Unit, Kids Research Institute, Children’s Hospital at Westmead, Westmead, NSW 2145, Australia

13. Division of Child and Adolescent Health, University of Sydney, Sydney, NSW 2145, Australia

Abstract

Precision medicine programs aim to utilize novel technologies to identify personalized treatments for children with cancer. Delivering these programs requires interdisciplinary efforts, yet the many groups involved are understudied. This study explored the experiences of a broad range of professionals delivering Australia’s first precision medicine trial for children with poor-prognosis cancer: the PRecISion Medicine for Children with Cancer (PRISM) national clinical trial of the Zero Childhood Cancer Program. We conducted semi-structured interviews with 85 PRISM professionals from eight professional groups, including oncologists, surgeons, clinical research associates, scientists, genetic professionals, pathologists, animal care technicians, and nurses. We analyzed interviews thematically. Professionals shared that precision medicine can add complexity to their role and result in less certain outcomes for families. Although many participants described experiencing a greater emotional impact from their work, most expressed very positive views about the impact of precision medicine on their profession and its future potential. Most reported navigating precision medicine without formal training. Each group described unique challenges involved in adapting to precision medicine in their profession. Addressing training gaps and meeting the specific needs of many professional groups involved in precision medicine will be essential to ensure the successful implementation of standard care.

Funder

Luminesce Alliance—Innovation for Children’s Health

University of Sydney

UNSW Sydney

Cancer Institute Translational Program

Children’s Cancer Institute and the Kids Cancer Centre, Sydney Children’s Hospital

NHMRC of Australia

CIBC Children’s Foundation Chair in Child Health Research

Kids with Cancer Foundation

Publisher

MDPI AG

Subject

Medicine (miscellaneous)

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