It provides families with other avenues for treatment when there are no other options Surgeons' perspectives of being part of a precision medicine trial for poor prognosis paediatric cancer patients: A short report

Author:

Daly Rebecca12ORCID,Hetherington Kate12ORCID,Wadling Bethany R.123,Jacobs Chris3,Karpelowsky Jonathan456,Wakefield Claire E.12

Affiliation:

1. Discipline of Paediatrics and Child Health, School of Clinical Medicine UNSW Medicine & Health, UNSW Sydney New South Wales Australia

2. Behavioural Sciences Unit, Kids Cancer Centre Sydney Children's Hospital Randwick New South Wales Australia

3. Graduate School of Health University of Technology Sydney Sydney New South Wales Australia

4. Department of Paediatric Surgery Children's Hospital at Westmead Westmead New South Wales Australia

5. Children's Cancer Research Unit Kids Research Institute, Children's Hospital at Westmead Westmead New South Wales Australia

6. Division of Child and Adolescent Health University of Sydney Camperdown New South Wales Australia

Abstract

AbstractObjectivePrecision medicine is transforming cancer treatment, yet the perspectives of surgeons who often play a critical role in the delivery of precision medicine remain understudied.MethodsWe conducted semi‐structured interviews with 13 surgeons involved in a precision medicine trial for children with poor prognosis cancer. We explored knowledge of genetics, confidence with somatic and germline results, ratings of benefit to stakeholders and willingness to undertake surgical procedures.ResultsSurgeons generally had positive attitudes towards precision medicine but expressed concerns about families' unrealistic expectations, mixed opinions on the benefits and the use of research‐only biopsies. Most surgeons rated their genetics knowledge as ‘good’ (69%) and felt ‘very confident’ in identifying genetic specialists (66%), but ‘not confident’ (66.6%) in making treatment recommendations. Surgeons' willingness to undertake a procedure was influenced by potential patient benefit.ConclusionsOur findings support the need for more workforce and training support for surgeons to fully engage with precision medicine.

Publisher

Wiley

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