Affiliation:
1. Department of Orthopedics, Hand and Microsurgery, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital of Central South University, Changsha 410008, China
Abstract
Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease, which is one of the common causes of hip pain and dysfunction. ONFH has a very high disability rate, which is associated with a heavy burden to patients, families, and society. The pathogenesis of ONFH is not completely clear. At present, it is believed that it mainly includes coagulation dysfunction, abnormal lipid metabolism, an imbalance of osteogenic/adipogenic differentiation, and poor vascularization repair. The prevention and treatment of ONFH has always been a great challenge for clinical orthopedic surgeons. However, recent studies have emphasized that the use of mesenchymal stem cells (MSCs) to treat steroid-induced ONFH (SONFH) is a promising therapy. This review focuses on the role and molecular mechanism of epigenetic regulation in the progress of MSCs in the treatment of SONFH, and discusses the significance of the latest research in the treatment of SONFH from the perspective of epigenetics.
Funder
National Natural Science Foundation of China
Subject
Molecular Biology,Biochemistry
Reference107 articles.
1. Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version);Zhao;J. Orthop. Transl.,2020
2. Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today? A Ten-Year Update;Mont;J. Bone Jt. Surg. Am. Vol.,2015
3. The natural history of untreated asymptomatic osteonecrosis of the femoral head: A systematic literature review;Mont;J. Bone Jt. Surg. Am. Vol.,2010
4. Current concepts on the pathogenesis and natural history of steroid-induced osteonecrosis;Powell;Clin. Rev. Allergy Immunol.,2011
5. Advances in experimental models of osteonecrosis of the femoral head;Li;J. Orthop. Transl.,2023