Use and Quality of Blood Cultures for the Diagnosis of Bloodstream Infections: A Cross-Sectional Study in the Ho Teaching Hospital, Ghana, 2019

Use and Quality of Blood Cultures for the Diagnosis of Bloodstream Infections: A Cross-Sectional Study in the Ho Teaching Hospital, Ghana, 2019–2021

Published:2023-08-23 Issue:17 Volume:20 Page:6631
ISSN:1660-4601
Container-title:International Journal of Environmental Research and Public Health
language:en
Short-container-title:IJERPH

Author:

Boakye-Yiadom Emily¹²^ORCID,Najjemba Robinah³^ORCID,Thekkur Pruthu⁴^ORCID,Labi Appiah-Korang⁵,Gil-Cuesta Julita⁶^ORCID,Asafo-Adjei Karikari²,Mensah Prosper²,van Boetzelaer Elburg⁷,Jessani Nasreen S.⁸⁹^ORCID,Orish Verner Ndudri¹¹⁰

Affiliation:

1. Department of Microbiology and Immunology, University of Health and Allied Sciences, Ho PMB 31, Volta Region, Ghana

2. Laboratory Department, Ho Teaching Hospital, Ho P.O. Box MA 374, Volta Region, Ghana

3. Independent Public Health Consultant, 1202 Geneva, Switzerland

4. International Union Against Tuberculosis and Lung Disease, 68 Boulevard Saint Michel, 75006 Paris, France

5. Ghana Country Office, World Health Organization, 7 Ameda Street, Roman Ridge, Accra P.O. Box MB 142, Ghana

6. Luxembourg Operational Research Unit, Operational Centre Brussels, Médecins Sans Frontières, Rue Arbre Benit 46, 1050 Brussels, Belgium

7. Luxembourg Operational Research Unit, Médecins Sans Frontières, 68 Rue de Gasperich, L-1617 Luxembourg, Luxembourg

8. Centre for Evidence-Based Health Care, Division of Epidemiology and Biostatistics, Department of Global Health, Stellenbosch University, Tygerburg 7505, South Africa

9. Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA

10. Sickle Cell Disease Unit, Department of Internal Medicine, Ho Teaching Hospital, Ho P.O. Box MA 374, Volta Region, Ghana

Abstract

Blood Culture and Drug Susceptibility Testing (CDST) remains vital for the diagnosis and management of bloodstream infections (BSIs). While the Ghana National Standard Treatment Guidelines require CDST to be performed in each case of suspected or clinically diagnosed BSI, these are poorly adhered to in the Ho Teaching Hospital (HTH). This study used secondary medical and laboratory records to describe blood CDST requests by clinicians and the quality of CDST processes for the diagnosis of BSI among patients admitted to HTH from 2019 to 2021. Of 4278 patients, 33% were infants. Pneumonia and neonatal sepsis cases were 40% and 22%, respectively. Only 8% (351/4278) had blood CDST requested. Of 94% (329/351) blood CDST processed and reported, only 7% (22/329) were culture-positive, with likely contaminants being recovered from 16% (52/329) of the specimens. The duration from admission to request was 2 days (IQR: 0–5), and Further qualitative studies must be conducted to understand the reasons for low blood CDST utilisation among clinicians and the patient outcomes. Targeted interventions are required to enhance the utilisation of blood CDST by clinicians and the quality of laboratory processes.

Funder

National Institute of Health Research

Publisher

MDPI AG

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Link

https://www.mdpi.com/1660-4601/20/17/6631/pdf

Reference64 articles.

1. Forbes, B.A., Sahm, D.F., and Weissfeld, A.S. (2007). Bailey and Scott’s Diagnostic Microbiology, Mosby Elsevier. [12th ed.].

2. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021;Evans;Crit. Care Med.,2021

3. Mahon, C.R., Lehman, D.C., and Manusells, G. (1996). Textbook of Diagnostic Microbiology, Saunders Elsevier. [5th ed.].

4. Overall Burden of Bloodstream Infection and Nosocomial Bloodstream Infection in North America and Europe;Goto;Clin. Microbiol. Infect.,2013

5. World Health Organization (2017). Global Action Plan on Antimicrobial Resistance, World Health Organization.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Use and Quality of Blood Cultures for the Diagnosis of Bloodstream Infections: A Cross-Sectional Study in the Ho Teaching Hospital, Ghana, 2019–2021;International Journal of Environmental Research and Public Health;2023-08-23