The Concept of Using 2D Self-Assembly of Magnetic Nanoparticles for Bioassays

Author:

Marć Maciej1ORCID,Wolak Wiktor1ORCID,Drzewiński Andrzej1ORCID,Mudry Stepan2ORCID,Shtablavyi Ihor2ORCID,Dudek Mirosław R.1ORCID

Affiliation:

1. Institute of Physics, University of Zielona Góra, ul. Szafrana 4a, 65-069 Zielona Góra, Poland

2. Department of Metal Physics, Ivan Franko National University of Lviv, 8, Kyrylo & Mephodiy Street, 79005 Lviv, Ukraine

Abstract

It can be observed that magnetic iron-oxide nanoparticles are increasingly used in bioassay methods. This is due to their stability in aqueous solutions, ease of functionalization, biocompatibility and very low toxicity. Here, we show that the recent discovery of the ability of magnetic nanoparticles to self-assemble into 2D structures of ordered chains may be exploited for bioassays. This would open up the possibility of controlled immobilization of proteins, enzymes, DNA or RNA and other molecular systems on spatially ordered nanostructures. In this work, fluorescein was used as an example. Also shown is the possibility of using Raman spectroscopy to analyze material accumulated on such structures. The observed formation of regularly spaced chains of magnetic nanoparticles takes place during the drying process of a thin layer of magnetic liquid placed on an appropriately prepared low-density polyethylene (LDPE) film.

Publisher

MDPI AG

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