Impact of Particle Size on the Nonlinear Magnetic Response of Iron Oxide Nanoparticles during Frequency Mixing Magnetic Detection
Author:
Pourshahidi Ali Mohammad1ORCID, Jean Neha1ORCID, Kaulen Corinna2ORCID, Jakobi Simon3ORCID, Krause Hans-Joachim1ORCID
Affiliation:
1. Institute of Biological Information Processing, Bioelectronics (IBI-3), Forschungszentrum Jülich, 52425 Jülich, Germany 2. Ostbayerische Technische Hochschule Regensburg, 93053 Regensburg, Germany 3. RWTH Aachen, Institute of Inorganic Chemistry, 52074 Aachen, Germany
Abstract
Magnetic nanoparticles (MNPs), particularly iron oxide nanoparticles (IONPs), play a pivotal role in biomedical applications ranging from magnetic resonance imaging (MRI) enhancement and cancer hyperthermia treatments to biosensing. This study focuses on the synthesis, characterization, and application of IONPs with two different size distributions for frequency mixing magnetic detection (FMMD), a technique that leverages the nonlinear magnetization properties of MNPs for sensitive biosensing. IONPs are synthesized through thermal decomposition and subsequent growth steps. Our findings highlight the critical influence of IONP size on the FMMD signal, demonstrating that larger particles contribute dominantly to the FMMD signal. This research advances our understanding of IONP behavior, underscoring the importance of size in their application in advanced diagnostic tools.
Funder
Forschungszentrum Jülich GmbH the German Research Foundation DFG the research training group “mobilEM” the German Research Foundation
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