Author:
Su Xudong,Chen Yuelong,Zhan Qian,Zhu Bo,Chen Li,Zhao Chen,Yang Jianye,Wei Li,Xu Zhenghao,Wei Keyu,Huang Wei,Qin Leilei,Hu Ning
Abstract
The diagnosis of prosthetic joint infection (PJI) is still a challenge, the ratio of interleukin-6 (IL-6) to IL-4 in the joint fluid of knee or hip was used to analyze whether the diagnostic accuracy of PJI can be improved. Between January 2017 and May 2022, 180 patients who developed pain after revision total hip or knee arthroplasty were enrolled retrospectively. 92 patients of PJI and 88 of aseptic failure were included. PJI was as defined by the Musculoskeletal Infection Society (MSIS). The content of IL-6 and IL-4 in synovial fluid of knee or hip were measured, and the areas under the receiver operating characteristic curve (ROC) and IL-6/IL-4 curve were analyzed to obtain a better diagnostic effect. The area under the curve of IL-6/IL-4 in synovial fluid of knee or hip was 0.9623, which was more accurate than ESR 0.5994 and C-reactive protein 0.6720. The optimal threshold of IL-6/IL-4 ratio was 382.10. Its sensitivity and specificity were 81.32% and 98.86%, respectively. The positive predictive value for the diagnosis of PJI was 98.91%. This study showed that the level of IL-6/IL-4 in synovial fluid of knee or hip could further improve the diagnostic accuracy for PJI.
Funder
the key project of Chongqing Science and Health Joint Medical Research Project
General Project of National Natural Science Foundation of China
Chongqing Technology Innovation and Application Development Special Project
Excellent Project of Chongqing Overseas Returnee Entrepreneurship and Innovation Support Program
Cited by
2 articles.
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