High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia-Reference-Cited by-同舟云学术

High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia

Published:2023-09-23 Issue:10 Volume:14 Page:1853
ISSN:2073-4425
Container-title:Genes
language:en
Short-container-title:Genes

Author:

Uricoechea Patiño Daniel¹,Collins Andrew²^ORCID,García Oscar Julián Romero³,Santos Vecino Gustavo⁴,Cuenca José Vicente Rodríguez⁵,Bernal Jaime E.⁶,Benavides Benítez Escilda⁶,Vergara Muñoz Saray⁶,Briceño Balcázar Ignacio¹

Affiliation:

1. Doctoral Program in Biosciences, Human Genetics Group, Faculty of Medicine, University of La Sabana, Chía 250001, Colombia

2. Human Genetics & Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK

3. Genetics Group, National Institute of Legal Medicine and Forensic Sciences, Bogotá 110311, Colombia

4. Department of Anthropology, Faculty of Social and Human Science, Universidad de Antioquia, Medellín 050010, Colombia

5. Research Group in Biological Anthropology, Universidad Nacional de Colombia, Bogotá 111321, Colombia

6. Faculty of Medicine, University of Sinú, Cartagena de Indias 130011, Colombia

Abstract

The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally inherited and has a higher mutation rate compared to nuclear DNA. To determine the genetic structure of three Colombian pre-Hispanic populations and compare them with current populations, we determined the haplotypes from human bone remains by sequencing several mitochondrial DNA segments. A wide variety of mitochondrial polymorphisms were obtained from 33 samples. Our results support a high population heterogeneity among pre-Hispanic populations in Colombia.

Funder

Universidad de La Sabana

Publisher

MDPI AG

Subject

Genetics (clinical),Genetics

Link

https://www.mdpi.com/2073-4425/14/10/1853/pdf

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