Adipokines in Sleep Disturbance and Metabolic Dysfunction: Insights from Network Analysis

Author:

Wei Zhikui,Chen YouORCID,Upender Raghu P.

Abstract

Adipokines are a growing group of secreted proteins that play important roles in obesity, sleep disturbance, and metabolic derangements. Due to the complex interplay between adipokines, sleep, and metabolic regulation, an integrated approach is required to better understand the significance of adipokines in these processes. In the present study, we created and analyzed a network of six adipokines and their molecular partners involved in sleep disturbance and metabolic dysregulation. This network represents information flow from regulatory factors, adipokines, and physiologic pathways to disease processes in metabolic dysfunction. Analyses using network metrics revealed that obesity and obstructive sleep apnea were major drivers for the sleep associated metabolic dysregulation. Two adipokines, leptin and adiponectin, were found to have higher degrees than other adipokines, indicating their central roles in the network. These adipokines signal through major metabolic pathways such as insulin signaling, inflammation, food intake, and energy expenditure, and exert their functions in cardiovascular, reproductive, and autoimmune diseases. Leptin, AMP activated protein kinase (AMPK), and fatty acid oxidation were found to have global influence in the network and represent potentially important interventional targets for metabolic and sleep disorders. These findings underscore the great potential of using network based approaches to identify new insights and pharmaceutical targets in metabolic and sleep disorders.

Publisher

MDPI AG

Subject

General Earth and Planetary Sciences,General Engineering,General Environmental Science

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Sleep and cardiometabolic risk. Narrative revision;Clínica e Investigación en Arteriosclerosis (English Edition);2024-01

2. Adipokines and Inflammatory Markers in Acute Myocardial Infarction Patients with and without Obstructive Sleep Apnea: A Comparative Analysis;International Journal of Molecular Sciences;2023-09-28

3. Influence of nutrition and food on sleep—is there evidence?;Sleep and Breathing;2023-09-23

4. Sueño y riesgo cardiometabólico. Revisión narrativa;Clínica e Investigación en Arteriosclerosis;2023-09

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