Adipokines and Inflammatory Markers in Acute Myocardial Infarction Patients with and without Obstructive Sleep Apnea: A Comparative Analysis

Author:

Vega-Jasso Ana L.1,Amezcua-Guerra Luis M.2ORCID,González-Pacheco Héctor3ORCID,Sandoval-Zárate Julio2ORCID,González-Díaz César A.4,Escobar-Alvarado Jennifer5,Manzano-Luna Jennifer D.6ORCID,Brianza-Padilla Malinalli2ORCID

Affiliation:

1. Master of Health Sciences, School of Medicine, Instituto Politécnico Nacional, Ciudad de México 07738, Mexico

2. Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico

3. Coronary Care Unit, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico

4. Postgraduate Studies and Research Section, School of Medicine, Instituto Politécnico Nacional, Ciudad de México 07738, Mexico

5. Sleep Laboratory, UNAM-INC Translational Research Unit, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico

6. Red MEDICI, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla 54090, Mexico

Abstract

An association has been suggested between acute myocardial infarction (AMI) and obstructive sleep apnea (OSA). Considering the role of adipose-tissue-derived inflammatory mediators (adipokines) and the shared risk factor of obesity in OSA and AMI, this study aimed to investigate the involvement of adipokines in AMI patients with and without OSA. Serum levels of adipokines and inflammatory mediators were quantified, and home respiratory polygraphy was conducted. A total of 30 AMI patients and 25 controls were included. Patients with AMI exhibited elevated levels of resistin (7.4 vs. 3.7 ng/mL), interleukin-6 (8.8 vs. 1.3 pg/mL), and endothelin-1 (3.31 vs. 1.8 pg/mL). Remarkably, AMI patients with concomitant OSA exhibited higher levels of resistin (7.1 vs. 3.7 ng/mL), interleukin-6 (8.9 vs. 1.3 pg/mL), endothelin-1 (3.2 vs. 1.8 pg/mL), creatin kinase (1430 vs. 377 U/L), creatine kinase-MB (64.6 vs. 9.7 ng/mL), and troponin T (2298 vs. 356 pg/mL) than their non-OSA counterparts. Leptin showed a correlation with OSA severity markers. OSA was associated with greater cardiac damage in AMI patients. Our findings underscore that adipokines alone are not sufficient to discriminate the risk of AMI in the presence of OSA. Further research is necessary to determine the potential mechanisms contributing to exacerbated cardiac damage in patients with both conditions.

Funder

Instituto Nacional de Cardiología Ignacio Chávez

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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