NUC041, a Prodrug of the DNA Methytransferase Inhibitor 5-aza-2′,2′-Difluorodeoxycytidine (NUC013), Leads to Tumor Regression in a Model of Non-Small Cell Lung Cancer-Reference-Cited by-同舟云学术

NUC041, a Prodrug of the DNA Methytransferase Inhibitor 5-aza-2′,2′-Difluorodeoxycytidine (NUC013), Leads to Tumor Regression in a Model of Non-Small Cell Lung Cancer

Published:2018-04-23 Issue:2 Volume:11 Page:36
ISSN:1424-8247
Container-title:Pharmaceuticals
language:en
Short-container-title:Pharmaceuticals

Author:

Daifuku Richard,Grimes Sheila,Stackhouse Murray

Publisher

MDPI AG

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

http://www.mdpi.com/1424-8247/11/2/36/pdf

Reference49 articles.

1. The Key Role of Epigenetics in Human Disease Prevention and Mitigation

2. DNA methyltransferase inhibitors and their emerging role in epigenetic therapy of cancer;Gnyszka;Anticancer Res.,2013

3. Oral and intravenous pharmacokinetics of 5-fluoro-2′-deoxycytidine and THU in cynomolgus monkeys and humans

4. Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4′-thio-2′-deoxycytidine and 5-aza-4′-thio-2′-deoxycytidine

5. Highlights of Prescribing Information https://www.otsuka-us.com/media/static/DACOGEN-PI.pdf

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3. Regioselective synthesis and anticancer evaluation of H2O2-activable nucleosides;Chemical Communications;2020

4. Pharmacoepigenetics of Novel Nucleoside DNA Methyltransferase Inhibitors;Pharmacoepigenetics;2019

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